Endocrine Abstracts

Introduction: In sporadic acromegaly, downregulation of AIP protein of the adenomas associates with invasive tumour features and reduced response to somatostatin analogue treatment. AIP is a regulator of Gαi signaling, but it is not known how the biological function of the Gαi pathway is controlled.Aim: To study somatic GNAS and AIP mutation status, AIP and Gαi-2 protein expressions, Ki67 proliferation indices, and clinical parameters in p...

Introduction: Previously, impaired health-related quality of life (HRQoL) was reported in patients with functional pituitary adenomas (FPA) and/or hypopituitarism. Our aim was to assess HRQoL in a cohort of FPA patients who underwent transsphenoidal surgery as primary treatment at our University Central Hospital between years 2000 and 2010.Design: A cross-sectional study including an age- and gender-standardized sample of the general population.<p cl...